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KMID : 1033620190460030099
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Clinical and Experimental Reproductive Medicine
2019 Volume.46 No. 3 p.99 ~ p.106
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Understanding the molecular mechanisms of bisphenol A action in spermatozoa
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Rahman Md Saidur
Pang Myung-Geol
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Abstract
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Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of interfering with the normal function of the endocrine system in the body. Exposure to this chemical from BPA-containing materials and the environment is associated with deleterious health effects, including male reproductive abnormalities. A search of the literature demonstrated that BPA, as a toxicant, directly affects the cellular oxidative stress response machinery. Because of its hormone-like properties, it can also bind with specific receptors in target cells. Therefore, the tissue-specific effects of BPA mostly depend on its endocrine-disrupting capabilities and the expression of those particular receptors in target cells. Although studies have shown the possible mechanisms of BPA action in various cell types, a clear consensus has yet to be established. In this review, we summarize the mechanisms of BPA action in spermatozoa by compiling existing information in the literature.
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KEYWORD
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Bisphenol A, Endocrine disruptors, Mechanism of action, Oxidative stress, Spermatozoa
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